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Invitrogen
EKLF Polyclonal Antibody
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EKLF Antibody (PA5-86441) in WB
Western blot analysis of EKLF in Lane 1: C6 whole cell lysate (40 µg), Lane 2: SP2/0 whole cell lysate (40 µg), Lane 3: MCF-7 whole cell lysate (40 µg), Lane 4: K562 whole cell lysate (40 µg). Sample was incubated with EKLF polyclonal antibody (Product # PA5-86441) using a 1:500 dilution.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-86441
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 288-335 of Human EKLF.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
KLF1 is a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant Inblood phenotype.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; Kruppel like factor 1; Kruppel-like factor 1 (erythroid); neonatal anemia; unnamed protein product
基因别名: CDAN4A; CDAN4B; EKLF; EKLF/KLF1; Nan
UniProt ID: (Human) Q13351
Entrez Gene ID: (Human) 10661, (Mouse) 16596, (Rat) 304666
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
ubiquitin binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein domain specific binding
DNA-binding transcription factor binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
erythrocyte differentiation
protein destabilization
positive regulation of transcription, DNA-templated
maternal process involved in female pregnancy
cellular response to endothelin
in utero embryonic development
liver development
chromatin remodeling
apoptotic process
positive regulation of gene expression
embryonic hemopoiesis
erythrocyte maturation
positive regulation of transcription from RNA polymerase II promoter
erythrocyte development
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