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Invitrogen
MED14 Polyclonal Antibody
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MED14 Antibody (PA5-87913) in WB
Western blot analysis of MED14 in extracts of various cell lines. Samples were incubated with MED14 Polyclonal antibody (Product # PA5-87913) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87913
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 470-650 of human MED14 (NP_0042202)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
3.54 mg/mL
规格
354 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LDQATLDDME KSVNDDMKRI IPWIQQLKFW LGQQRCKQSI KHLPTISSET LQLSNYSTHP IGNLSKNKLF IKLTRLPQYY IVVEMLEVPN KPTQLSYKYY FMSVNAADRE DSPAMALLLQ QFKENIQDLV FRTKTGKQTR TNAKRKLSDD PCPVESKKTK RAGEMCAFNK VLAHFVAMCD T; Positive Samples: HeLa, SW480, Jurkat, Mouse brain, Mouse pancreas; Cellular Location: Nucleus
靶标信息
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cofactor required for Sp1 transcriptional activation subunit 2; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa); cofactor required for Sp1 transcriptional activation, subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; Mediator of RNA polymerase II transcription subunit 14; MGC104513; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170
基因别名: 9930001L01Rik; AU041628; Crsp2; ENSMUSG00000073278; Gm641; Med14; ORF1; RGD1560170; Trap170
UniProt ID: (Mouse) A2ABV5
Entrez Gene ID: (Mouse) 26896, (Rat) 317343
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
stem cell population maintenance
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
biological_process
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