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Invitrogen
PDE1A Polyclonal Antibody
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PDE1A Antibody (PA5-87915) in WB
Western blot analysis of PDE1A in extracts of various cell lines. Samples were incubated with PDE1A Polyclonal antibody (Product # PA5-87915) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87915
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A (NP_0050102)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.68 mg/mL
规格
268 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EASKAETSSY VASSSTTIVG LHIADALRRS NTKGSMSDGS YSPDYSLAAV DLKSFKNNLV DIIQQNKERW KELAAQGESD LHKNSEDLVN AEEKHDETHS; Positive Samples: Mouse heart, Mouse brain, Mouse kidney, Rat heart, Rat brain
靶标信息
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1)that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3'-RACE clone 8 phosphodiesterase 1A; 3-RACE clone 8 phosphodiesterase 1A; 61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; HS MGC26303; MGC26303; phosphodiesterase-1A
基因别名: 3'-RACEclone8phosphodiesterase1A; 3-RACEclone8phosphodiesterase1A; AI987702; AW125737; Pde1a
UniProt ID: (Mouse) Q61481
Entrez Gene ID: (Mouse) 18573, (Rat) 81529
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
calmodulin binding
phosphoric diester hydrolase activity
hydrolase activity
cGMP binding
metal ion binding
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
phosphodiesterase
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