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Invitrogen
14-3-3 epsilon Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87995
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.64 mg/mL
Amount
64 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KGGEDKLKMI REYRQMVETE LKLICCDILD VLDKHLIPAA NTGESKVFYY KMKGDYHRYL AEFATGNDRK EAAENSLVAY KAASDIAMTE L
Positive Samples: HeLa, HepG2, NIH/3T3, SH-SY5Y, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Melanosome
Target Information
14-3-3 epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; MSF L; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
Gene Aliases: 14-3-3e; AU019196; Ywhae
UniProt ID: (Rat) P62260, (Mouse) P62259
Entrez Gene ID: (Rat) 29753, (Mouse) 22627
protein binding
protein kinase C inhibitor activity
potassium channel regulator activity
enzyme binding
protein domain specific binding
MHC class II protein complex binding
protein complex binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
protein heterodimerization activity
phosphoserine binding
phosphoprotein binding
ubiquitin protein ligase binding
scaffold/adaptor protein
transporter
neuron migration
protein targeting
signal transduction
substantia nigra development
hippocampus development
cerebral cortex development
negative regulation of protein dephosphorylation
regulation of membrane repolarization
negative regulation of protein serine/threonine kinase activity
regulation of potassium ion transmembrane transporter activity
negative regulation of peptidyl-serine dephosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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