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Invitrogen
NeuroD1 Polyclonal Antibody
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NeuroD1 Antibody (PA5-88138) in WB
Western blot analysis of NeuroD1 in extracts of various cell lines. Samples were incubated with NeuroD1 Polyclonal antibody (Product # PA5-88138) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88138
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_0024912)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.44 mg/mL
规格
144 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ NQDMPPHLPT ASASFPVHPY SYQSPGLPSP PYGTMDSSHV FHVKPPPHAY SAALEPFFES PLTDCTSPSF DGPLSPPLSI NGNFSFKHEP SAEFEKNYAF TMHYPAATLA GAQSHGSIFS GTAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD
Positive Samples: HepG2, Mouse brain; Cellular Location: Cytoplasm, Nucleus
靶标信息
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic helix-loop-helix factor 1; BHF-1; BHF1; neuro d1; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1
基因别名: Neurod; Neurod1
UniProt ID: (Rat) Q64289
Entrez Gene ID: (Rat) 29458
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription factor binding
sequence-specific DNA binding
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
transcription, DNA-templated
transcription from RNA polymerase II promoter
nucleocytoplasmic transport
nitric oxide mediated signal transduction
response to glucose
anterior/posterior pattern specification
dentate gyrus development
cerebellum development
signal transduction involved in regulation of gene expression
insulin secretion
hindbrain development
endocrine pancreas development
amacrine cell differentiation
enteroendocrine cell differentiation
response to drug
glucose homeostasis
camera-type eye development
positive regulation of apoptotic process
cell fate commitment
positive regulation of cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
embryonic organ morphogenesis
inner ear development
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of intestinal epithelial structure maintenance
regulation of cell cycle arrest
cellular response to glucose stimulus
negative regulation of type B pancreatic cell apoptotic process
positive regulation of transcription regulatory region DNA binding
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