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Invitrogen
GRASP1 Polyclonal Antibody
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GRASP1 Antibody (PA5-88318) in WB
Western blot analysis of GRASP1 in extracts of various cell lines. Samples were incubated with GRASP1 Polyclonal antibody (Product # PA5-88318) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88318
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 642-841 of human GRIPAP1 (NP_0645223)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
5.06 mg/mL
规格
506 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RSGLEELVLS EMNSPSRTQT GDSSSISSFS YREILREKES SAVPARSLSS SPQAQPPRPA ELSDEEVAEL FQRLAETQQE KWMLEEKVKH LEVSSASMAE DLCRKSAIIE TYVMDSRIDV SVAAGHTDRS GLGSVLRDLV KPGDENLREM NKKLQNMLEE QLTKNMHLHK DMEVLSQEIV RLSKECVGPP DPDLEPGETS; Positive Samples: U-87MG, Jurkat, HeLa, HepG2; Cellular Location: Early endosome
靶标信息
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GRIP-1; GRIP1; MPMGp800B12492Q3
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