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Invitrogen
PKLR Polyclonal Antibody
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PKLR Antibody (PA5-88337) in WB
Western blot analysis of PKLR in extracts of various cell lines. Samples were incubated with PKLR Polyclonal antibody (Product # PA5-88337) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 50s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88337
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 446-556 of human PKLR (NP_0002891)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.75 mg/mL
规格
75 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PLSRDPTEVT AIGAVEAAFK CCAAAIIVLT TTGRSAQLLS RYRPRAAVIA VTRSAQAARQ VHLCRGVFPL LYREPPEAIW ADDVDRRVQF GIESGKLRGF LRVGDLVIVV T; Positive Samples: BxPC-3, HepG2, 293T, Mouse kideny, Mouse liver, Mouse heart, Rat kidney
靶标信息
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: isozymes R/L; L-PK; Pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; Pyruvate kinase PKLR; pyruvate kinase, liver and red blood cell
基因别名: Pk-1; PK1; PKL; Pklg; Pklr; R-PK
UniProt ID: (Rat) P12928
Entrez Gene ID: (Mouse) 18770, (Rat) 24651
carbohydrate metabolic process
glycolytic process
ATP biosynthetic process
metabolic process
response to heat
response to lithium ion
phosphorylation
cellular response to insulin stimulus
response to ATP
pyruvate biosynthetic process
response to cAMP
response to other organism
response to hypoxia
response to nutrient
response to glucose
response to metal ion
response to organic cyclic compound
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
