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Invitrogen
UBR4 Polyclonal Antibody
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UBR4 Antibody (PA5-88406) in WB
Western blot analysis of UBR4 in extracts of HeLa cells. Samples were incubated with UBR4 Polyclonal antibody (Product # PA5-88406) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88406
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 4884-5183 of human UBR4 (NP_0658162)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.34 mg/mL
规格
234 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NIVHYDCHLA AVRLARGREE WESAALQNAN TKCNGLLPVW GPHVPESAFA TCLARHNTYL QECTGQREPT YQLNIHDIKL LFLRFAMEQS FSADTGGGGR ESNIHLIPYI IHTVLYVLNT TRATSREEKN LQGFLEQPKE KWVESAFEVD GPYYFTVLAL HILPPEQWRA TRVEILRRLL VTSQARAVAP GGATRLTDKA VKDYSAYRSS LLFWALVDLI YNMFKKVPTS NTEGGWSCSL AEYIRHNDMP IYEAADKALK TFQEEFMPVE TFSEFLDVAG LLSEITDPES FLKDLLNSVP; Positive Samples: HeLa; Cellular Location: Cytoplasm, Membrane, Multi-pass membrane protein, Nucleus, cytoskeleton
靶标信息
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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