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Cathepsin L Polyclonal Antibody
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FIGURE: 1 / 3
Cathepsin L Antibody (PA5-88413) in WB
Western blot analysis of Cathepsin L in extracts from LO2 cells. Samples were incubated with Cathepsin L Polyclonal antibody (Product # PA5-88413) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-88413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human Cathepsin L/V/K/H (NP_0019031)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.99 mg/mL
Amount
99 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: APRSVDWREK GYVTPVKNQG QCGSCWAFSA TGALEGQMFR KTGRLISLSE QNLVDCSGPQ GNEGCNGGLM DYAFQYVQDN GGLDSEESYP YEATEESCKY NPKYSVANDT GFVDIPKQEK ALMKAVATVG PISVAIDAGH ESFLFYKEGI YFEPDCSSED MDHGVLVVGY GFESTESDNN KYWLVKNSWG EEWGMGGYVK MAKDRRNHCG IASAASYPTV; Positive Samples: LO2, 293T, Rat kidney; Cellular Location: Lysosome
Target Information
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cathepsin L1; CP-2; Cyclic protein 2; Major excreted protein; MEP; Procathepsin L
Gene Aliases: CATHL; CatL; Ctsl; Ctsl1
UniProt ID: (Rat) P07154
Entrez Gene ID: (Rat) 25697
fibronectin binding
aminopeptidase activity
cysteine-type endopeptidase activity
collagen binding
cysteine-type peptidase activity
cysteine-type carboxypeptidase activity
kininogen binding
protein complex binding
peptide binding
histone binding
proteoglycan binding
serpin family protein binding
cysteine protease
adaptive immune response
proteolysis
cell communication
spermatogenesis
male gonad development
cellular response to starvation
response to glucose
multicellular organism aging
negative regulation of keratinocyte proliferation
response to organic cyclic compound
protein processing
protein autoprocessing
nerve development
collagen catabolic process
hair follicle morphogenesis
response to gonadotropin
decidualization
autophagic cell death
response to glucocorticoid
proteolysis involved in cellular protein catabolic process
Sertoli cell differentiation
epithelial tube branching involved in lung morphogenesis
cellular response to thyroid hormone stimulus
regulation of actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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