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Invitrogen
PP1 alpha Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88566
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 230-330 of human PPP1CA (NP_0026991)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.58 mg/mL
Amount
58 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: DU145, MCF7, NIH3T3, HepG2, Mouse brain; Cellular Location: Cytoplasm, Nucleus, nucleolus, nucleoplasm
Immunogen sequence: EVVAKFLHKH DLDLICRAHQ VVEDGYEFFA KRQLVTLFSA PNYCGEFDNA GAMMSVDETL MCSFQILKPA DKNKGKYGQF SGLNPGGRPI TPPRNSAKAK K
Target Information
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GADD34; MGC15877; MGC1674; PP-1A; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; testicular tissue protein Li 155; unnamed protein product
Gene Aliases: dism2; PP-1A; PP1A; PP1alpha; PPP1A; Ppp1c
UniProt ID: (Human) P62136, (Rat) P62138, (Mouse) P62137
Entrez Gene ID: (Human) 5499, (Rat) 24668, (Mouse) 19045
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
protein binding
protein phosphatase 1 binding
hydrolase activity
phosphatase activity
ribonucleoprotein complex binding
macromolecular complex binding
transition metal ion binding
cadherin binding involved in cell-cell adhesion
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
promoter clearance from RNA polymerase II promoter
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
protein dephosphorylation
response to lead ion
lung development
circadian regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
telomere maintenance in response to DNA damage
positive regulation of glycogen biosynthetic process
branching morphogenesis of an epithelial tube
protein stabilization
cell-cell adhesion
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of translational initiation in response to stress
positive regulation of Ras protein signal transduction
regulation of canonical Wnt signaling pathway
telomere maintenance
glycogen metabolic process
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
regulation of translation
negative regulation of triglyceride catabolic process
double-strand break repair via alternative nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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