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Invitrogen
PRDX5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88706
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 53-214 of human Peroxiredoxin 5 (PRDX5) (NP_0362262)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.95 mg/mL
规格
195 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAPIKVGDAI PAVEVFEGEP GNKVNLAELF KGKKGVLFGV PGAFTPGCSK THLPGFVEQA EALKAKGVQV VACLSVNDAF VTGEWGRAHK AEGKVRLLAD PTGAFGKETD LLLDDSLVSI FGNRRLKRFS MVVQDGIVKA LNVEPDGTGL TCSLAPNIIS QL; Positive Samples: HeLa, 293T, HepG2, U-251MG, Mouse kidney, Mouse liver, Rat brain, Rat liver; Cellular Location: Cytoplasm, Mitochondrion, Peroxisome
靶标信息
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 2D-0014IV; peroxiredoxin 6; Peroxiredoxin V; Peroxiredoxin-5, mitochondrial; Peroxisomal antioxidant enzyme; peroxisomal membrane protein 20; PLP; Prx-V; Prx5; Thioredoxin peroxidase PMP20; thioredoxin reductase; Thioredoxin-dependent peroxiredoxin 5
基因别名: AOEB166; AOPP; Pmp20; Prdx5; Prdx6; PrxV
UniProt ID: (Mouse) P99029, (Rat) Q9R063
Entrez Gene ID: (Mouse) 54683, (Rat) 113898
RNA polymerase III regulatory region DNA binding
peroxidase activity
receptor binding
antioxidant activity
oxidoreductase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein dimerization activity
peroxiredoxin activity
peroxynitrite reductase activity
oxidoreductase
apoptotic process
response to oxidative stress
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
cellular response to reactive oxygen species
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of oxidoreductase activity
oxidation-reduction process
regulation of apoptosis involved in tissue homeostasis
NADPH oxidation
reactive nitrogen species metabolic process
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