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Invitrogen
NFATC1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-90432
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.57 mg/mL
规格
157 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Jurkat, U-87MG, K-562, Mouse spleen; Cellular Location: Cytoplasm, Nucleus
靶标信息
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MGC138448; NF-ATc; NF-ATc1; NFAT tra; NFAT trans; NFAT transcription complex cytosolic component; nuclear factor of activated T cells; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor; transcription factor NF-ATc; unnamed protein product
基因别名: 2210017P03Rik; AI449492; AV076380; NF-ATC; NF-ATc1.2; NFAT2; NFATC; NFATC1; Nfatcb
Entrez Gene ID: (Human) 4772, (Rat) 100361818, (Mouse) 18018
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
FK506 binding
protein phosphatase 2B binding
mitogen-activated protein kinase p38 binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
RNA polymerase II transcription coactivator binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
Rel homology transcription factor
aortic valve morphogenesis
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
negative regulation of Wnt signaling pathway
calcineurin-NFAT signaling cascade
intracellular signal transduction
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
negative regulation of vascular smooth muscle cell differentiation
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
lymphangiogenesis
B-1a B cell differentiation
heart valve morphogenesis
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
calcium ion transport
heart development
positive regulation of gene expression
transition between fast and slow fiber
osteoclast differentiation
regulation of hair cycle
negative regulation of osteoblast differentiation
ventricular septum morphogenesis
patterning of lymph vessels
heart trabecula morphogenesis
negative regulation of stem cell proliferation
transcription, DNA-templated
cell quiescence
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