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Invitrogen
UBE2V2 Polyclonal Antibody
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UBE2V2 Antibody (PA5-93337) in IHC (P)
Immunohistochemistry analysis of UBE2V2 in paraffin-embedded rat spleen. Samples were incubated with UBE2V2 Polyclonal antibody (Product # PA5-93337) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-93337
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_0033411)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.68 mg/mL
规格
68 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN; Positive Samples: SW480, SKOV3, HeLa, HL-60, Mouse liver, Mouse skin, Rat liver, Rat brain
靶标信息
The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: meth; methyl methanesulfonate sensitive 2; Ubc-like protein MMS2; Ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; Ubiquitin-conjugating enzyme variant MMS2
基因别名: 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; MMS2; Ube2v2; Uev2
UniProt ID: (Rat) Q7M767, (Mouse) Q9D2M8
Entrez Gene ID: (Rat) 287927, (Mouse) 70620
DNA double-strand break processing
postreplication repair
positive regulation of neuron projection development
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
error-free postreplication DNA repair
negative regulation of neuron apoptotic process
positive regulation of DNA repair
positive regulation of synapse assembly
protein K63-linked ubiquitination
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