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Invitrogen

H-Ras Polyclonal Antibody

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H-Ras Polyclonal Antibody

Product Details

PA5-94930

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human GTPase HRAS (101-137aa KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLAR SY).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806736

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Brain Tissue, Mouse Brain Tissue, HEPA whole cell. IHC: mouse intestine tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins: H-, K-, N-Ras. Oncogenic mutations in Ras genes are present in ~30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibition of apoptosis. K-Ras mutations are common in pancreatic, colorectal and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies and hepatocellular carcinaoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; GTPase HRas; GTPase Hras1; H-ras 1 protein; H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene 1; p21ras; Transforming protein p21

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Gene Aliases: c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras; Hras-1; HRAS1; Kras2; ras

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UniProt ID: (Mouse) Q61411, (Rat) P20171

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Entrez Gene ID: (Mouse) 15461, (Rat) 293621

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Function(s)
nucleotide binding protein binding GTP binding protein C-terminus binding small GTPase
Process(es)
positive regulation of protein phosphorylation endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint signal transduction small GTPase mediated signal transduction Ras protein signal transduction cell aging cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell migration negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation protein heterooligomerization positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing cellular senescence intrinsic apoptotic signaling pathway positive regulation of ruffle assembly positive regulation of actin cytoskeleton reorganization positive regulation of miRNA metabolic process visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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