Invitrogen

CCR6 Polyclonal Antibody

Name: CCR6 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-94947
Availability: InStock

查看其他33个CCR6抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

图: 1 / 1

CCR6 Antibody (PA5-94947) in WB

Western blot analysis of CCR6 in Lane 1: rat liver tissue lysate, Lane 2: SW620 cell lysate, Lane 3: CEM cell lysate. Samples were incubated with CCR6 polyclonal antibody (Product # PA5-94947).

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image CCR6 Polyclonal Antibody

产品信息

PA5-94947

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the C-terminus of human CCR6 (358-374aa RQTSETADNDNASSFTM).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2806753

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Liver Tissue, SW620 Cell, CEM Cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

CD196, also known as CCR6, is a member of the beta chemokine receptor family and is characterized by a seven transmembrane structure similar to G protein-coupled receptors. This receptor uniquely binds to macrophage inflammatory protein 3 alpha (MIP-3alpha/CCL20), which acts as a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CCR6 is preferentially expressed by immature dendritic cells and memory T cells, playing a crucial role in host defense and inflammation at epithelial sites. It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it regulates the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Additionally, CCR6 has been implicated in the differentiation of Th17 cells and the development of CD4+FoxP3+ regulatory T cells, highlighting its role in immune regulation. Alternatively spliced transcript variants encoding the same protein have been described for this gene, further emphasizing its functional diversity in immune processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-C chemokine receptor type 6; C-C CKR-6; CC chemokine receptor 6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; Chemokine receptor-like 3; CKR-L3; CKR6; DRY-6; DRY6; G protein-coupled receptor; G protein-coupled receptor 29; G-protein coupled receptor 29; GPR-CY4; GPRCY4; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; Unknown; unnamed protein product

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基因别名: BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CCR6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; KY411; STRL22

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UniProt ID: (Mouse) O54689

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Entrez Gene ID: (Human) 1235, (Rat) 308163, (Mouse) 12458

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功能

G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity C-C chemokine binding signaling receptor activity molecular_function signal transducer activity

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