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Invitrogen
KRIT1 Polyclonal Antibody
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图: 1 / 1
KRIT1 Antibody (PA5-95383) in WB
Western blot analysis of KRIT1 in rat cardiac muscle extract (lane 1), NIH3T3 whole cell lysates (lane 2) and HeLa whole cell lysates (lane 3). Samples were incubated with KRIT1 polyclonal antibody (Product # PA5-95383) using a 0.5 µg/mL dilution. developed was performed using enhanced chemiluminescence (ECL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95383
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human KRIT1 (703-736aa ENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat cardiac muscle tissue, NIH3T3 whole cell, HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat-containing protein Krit1; ankyrin-repeat containing protein; Cerebral cavernous malformations 1 protein; Cerebral cavernous malformations 1 protein homolog; FERM domain-containing protein; Krev interaction trapped 1; Krev interaction trapped protein 1; KRIT1; unnamed protein product
基因别名: 2010007K12Rik; A630036P20Rik; AA432855; AI450393; AI643869; BB155247; BB235701; CAM; CCM1; KRIT1; RGD1305929
UniProt ID: (Mouse) Q6S5J6
Entrez Gene ID: (Human) 889, (Rat) 362317, (Mouse) 79264
negative regulation of endothelial cell proliferation
endothelium development
small GTPase mediated signal transduction
negative regulation of endothelial cell migration
negative regulation of angiogenesis
integrin activation
cell redox homeostasis
regulation of angiogenesis
regulation of establishment of cell polarity
negative regulation of endothelial cell apoptotic process
biological_process
positive regulation of protein binding
angiogenesis
regulation of catalytic activity
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