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Invitrogen
TGFBR1 Polyclonal Antibody
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TGFBR1 Antibody (PA5-95387) in WB
Western blot analysis of TGFBR1 in rat cardiac muscle extract (lane 1), mouse liver extract (lane 2) and HeLa whole cell lysates (lane 3). Samples were incubated with TGFBR1 polyclonal antibody (Product # PA5-95387) using a 0.5 µg/mL dilution. developed was performed using enhanced chemiluminescence (ECL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95387
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human TGFBR1 (149-186aa HNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTT).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat cardiac muscle tissue, mouse liver tissue, HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin receptor-like kinase 5; ESK2; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I
基因别名: Alk-5; ALK5; AU017191; Skr4; TbetaR-I; TbetaRI; Tgfbr1; Tgfr-1
UniProt ID: (Rat) P80204, (Mouse) Q64729
Entrez Gene ID: (Rat) 29591, (Mouse) 21812
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
receptor signaling protein activity
type II transforming growth factor beta receptor binding
ATP binding
growth factor binding
ubiquitin protein ligase binding
protein complex binding
SMAD binding
metal ion binding
protein heterodimerization activity
transforming growth factor beta binding
I-SMAD binding
nucleotide binding
transmembrane receptor protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
activation of MAPKK activity
skeletal system development
angiogenesis
response to hypoxia
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lens development in camera-type eye
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
embryo implantation
aging
positive regulation of cell proliferation
germ cell migration
male gonad development
response to toxic substance
post-embryonic development
anterior/posterior pattern specification
regulation of gene expression
positive regulation of gene expression
regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
response to organic cyclic compound
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
collagen fibril organization
positive regulation of cell growth
lung development
organ regeneration
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
activin receptor signaling pathway
response to prostaglandin E
intracellular signal transduction
regulation of growth
endothelial cell activation
negative regulation of apoptotic process
regulation of protein binding
endothelial cell migration
response to estrogen
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
protein autophosphorylation
thymus development
digestive tract development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
mesenchymal cell differentiation
artery morphogenesis
cell motility
positive regulation of cellular component movement
positive regulation of filopodium assembly
response to electrical stimulus
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
response to cholesterol
cellular response to transforming growth factor beta stimulus
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
embryo development
phosphorylation
cell differentiation
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