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Invitrogen
TSG101 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 291-390 of human TSG101/VPS23 (NP_0062831)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.16 mg/mL
Amount
116 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKKKDEELSS ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY
Positive Samples: HeLa, MCF7, K-562, Mouse spinal cord, Rat heart, Rat lung; Cellular Location: Cytoplasm, Late endosome membrane, Membrane, Nucleus, Peripheral membrane protein
Target Information
TSG101-4A10 recognizes TSG101 protein, the product of a recently identified Tumor Susceptibility Gene whose inactivation in mouse fibroblasts results in cell transformation and the ability of those cells to form tumors in nude mice. The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a leucine-zipper motif within a coiled-coil domain near the carboxyl terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CC2; ESCRT-I complex subunit TSG101; ESCRTI complex subunit TSG101; TSG 101; TSG101; Tumor supressor; tumor susceptibility gene 10; tumor susceptibility gene 101; tumor susceptibility protein; unnamed protein product
Gene Aliases: CC2; Rw; TSG10; VPS23
UniProt ID: (Human) Q99816, (Rat) Q6IRE4, (Mouse) Q61187
Entrez Gene ID: (Human) 7251, (Rat) 292925, (Mouse) 22088
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
regulation of transcription, DNA-templated
extracellular transport
negative regulation of epidermal growth factor-activated receptor activity
negative regulation of cell proliferation
endosome to lysosome transport
protein transport
cell differentiation
keratinocyte differentiation
negative regulation of epidermal growth factor receptor signaling pathway
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of MAP kinase activity
positive regulation of transcription, DNA-templated
viral budding
regulation of cell cycle
positive regulation of protein monoubiquitination
positive regulation of exosomal secretion
regulation of extracellular exosome assembly
positive regulation of viral budding via host ESCRT complex
exosomal secretion
positive regulation of ubiquitin-dependent endocytosis
macroautophagy
viral release from host cell
multivesicular body assembly
viral budding via host ESCRT complex
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
negative regulation of transcription, DNA-templated
membrane fission
autophagosome maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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