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Invitrogen

HDAC6 Polyclonal Antibody

查看其他27个HDAC6抗体

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HDAC6 Polyclonal Antibody

产品信息

PA5-95908

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HDAC6 (NP_0060352)
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.59 mg/mL

规格

59 µg

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2807710

产品详细信息

Immunogen sequence: MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG; Positive Samples: K-562, HeLa; Cellular Location: Cell projection, Cytoplasm, Nucleus, Perikaryon, axon, dendrite

靶标信息

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ16239; HDA6; histone deacetylase 5; histone deacetylase 6; histone deacetylase mHDA2; mHDA2; Protein deacetylase HDAC6; scurfy candidate 6; Tubulin-lysine deacetylase HDAC6

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基因别名: Hd6; Hdac5; Hdac6; mHDA2; Sfc6

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UniProt ID: (Mouse) Q9Z2V5

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Entrez Gene ID: (Rat) 84581, (Mouse) 15185

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功能
core promoter binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding hydrolase activity polyubiquitin binding ubiquitin protein ligase binding histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding ubiquitin binding tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding dynein complex binding actin binding histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
参与通路
protein polyubiquitination regulation of protein phosphorylation response to amphetamine protein deacetylation ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process intracellular protein transport negative regulation of microtubule depolymerization metabolic process positive regulation of cell proliferation response to toxic substance positive regulation of signal transduction response to organic substance regulation of receptor activity positive regulation of epithelial cell migration regulation of mitochondrion organization positive regulation of receptor biosynthetic process negative regulation of neuron projection development macroautophagy histone deacetylation axonal transport of mitochondrion neuron differentiation lysosome localization cellular response to oxidative stress peptidyl-lysine deacetylation response to immobilization stress cellular response to topologically incorrect protein regulation of gene expression, epigenetic ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein complex disassembly negative regulation of protein complex disassembly regulation of fat cell differentiation negative regulation of proteolysis negative regulation of axon extension involved in axon guidance positive regulation of dendrite morphogenesis response to corticosterone response to misfolded protein positive regulation of synaptic transmission, glutamatergic regulation of establishment of protein localization cellular response to hydrogen peroxide regulation of microtubule cytoskeleton organization aggresome assembly polyubiquitinated misfolded protein transport Hsp90 deacetylation response to growth factor cellular response to misfolded protein cellular response to parathyroid hormone stimulus response to dexamethasone positive regulation of chaperone-mediated protein complex assembly tubulin deacetylation positive regulation of tubulin deacetylation positive regulation of hydrogen peroxide-mediated programmed cell death negative regulation of protein acetylation positive regulation of oxidative stress-induced neuron death transcription, DNA-templated regulation of transcription, DNA-templated chromatin modification mitochondrion localization mitophagy in response to mitochondrial depolarization
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