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Invitrogen
EAAC1 Polyclonal Antibody
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EAAC1 Antibody (PA5-96218) in IHC (P)
Immunohistochemistry (Immunofluorescence) analysis of EAAC1 in mouse brain. Samples were incubated with EAAC1 Polyclonal antibody (Product # PA5-96218) using a dilution of 1:400 (40x lens). Perform microwave antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IF staining protocol. Blue: DAPI for nuclear staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96218
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.63 mg/mL
规格
163 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: SKOV3, HT-29; Cellular Location: Apical cell membrane, Cell membrane, Membrane, Multi-pass membrane protein
Immunogen sequence: AEDVTLIIAV DWLLDRFRTM VNVLGDAFGT GIVEKLSKKE LEQMDVSSEV NIVNPFALES TILDNEDSDT KKSYVNGGFA VDKSDTISFT QTSQF
靶标信息
L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: excitatory amino acid carrier 1; excitatory amino acid carrier 2; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; glutamate transporter mEAAC2; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 A1 (brain glutamate transporter); Solute carrier family 1 member 1; solute carrier family 1, member 1
基因别名: D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1; REAAC1; Slc1a1
UniProt ID: (Mouse) P51906, (Rat) P51907
Entrez Gene ID: (Mouse) 20510, (Rat) 25550
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
