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Invitrogen
ABCG1 Polyclonal Antibody
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ABCG1 Antibody (PA5-96284) in IHC (P)
Immunohistochemistry analysis of ABCG1 in paraffin-embedded human colon carcinoma. Samples were incubated with ABCG1 Polyclonal antibody (Product # PA5-96284) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96284
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 6-120 of human ABCG1 (NP_0049063)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.66 mg/mL
规格
66 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AAFSVGTAMN ASSYSAEMTE PKSVCVSVDE VVSSNMEATE TDLLNGHLKK VDNNLTEAQR FSSLPRRAAV NIEFRDLSYS VPEGPWWRKK GYKTLLKGIS GKFNSGELVA IMGPS
Positive Samples: SH-SY5Y, A-549, mouse lung, rat lung; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G, member 1; MGC34313; White protein homolog
基因别名: Abc8; Abcg1; AW413978; White; Wht1
UniProt ID: (Mouse) Q64343
Entrez Gene ID: (Rat) 85264, (Mouse) 11307
ATP binding
phospholipid transporter activity
cholesterol transporter activity
toxin transporter activity
sterol-transporting ATPase activity
glycoprotein transporter activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
cholesterol metabolic process
response to organic substance
regulation of cholesterol esterification
positive regulation of cholesterol efflux
negative regulation of lipid storage
cholesterol transport
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
phospholipid homeostasis
response to high density lipoprotein particle
toxin transport
transport
lipid transport
negative regulation of macrophage derived foam cell differentiation
transmembrane transport
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