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Invitrogen
DIAPH1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.66 mg/mL
Amount
66 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TEEKMRRAKL AKEKAEKERL EKQQKREQLI DMNAEGDETG VMDSLLEALQ SGAAFRRKRG PRQANRKAGC AVTSLLASEL TKDDAMAAVP AKVSKNSETF PTILEEAKEL VGRAS; Positive Samples: HL-60, MCF7, 293T, HepG2, Mouse liver, Mouse lung; Cellular Location: Cell membrane, Cell projection, Cytoplasm, cytoskeleton, ruffle membrane
Target Information
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: diaphanous 1; diaphanous-1; Diaphanous-related formin-1; DRF1; FLJ25265; mammalian diaphanous related formin 1; mDIA1; p140DIA; p140mDIA; Protein diaphanous homolog 1; similar to Drosophila diaphanous; unnamed protein product
Gene Aliases: D18Wsu154e; DFNA1; DIA1; DIAP1; DIAPH1; DRF1; hDIA1; LFHL1; mDia1; p140mDia; SCBMS
UniProt ID: (Mouse) O08808
Entrez Gene ID: (Human) 1729, (Mouse) 13367
cytoskeleton organization
brain development
sensory perception of sound
actin cytoskeleton organization
actin filament polymerization
neuron projection development
regulation of microtubule-based process
protein localization to microtubule
synaptic vesicle endocytosis
regulation of release of sequestered calcium ion into cytosol
regulation of cytoskeleton organization
cellular response to histamine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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