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Invitrogen
Beclin 1 Polyclonal Antibody
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Beclin 1 Antibody (PA5-96649) in WB
Western blot analysis of Beclin 1 in various lysates. Samples were incubated with Beclin 1 Polyclonal antibody (Product # PA5-96649) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96649
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Beclin 1 (NP_0037571)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.23 mg/mL
规格
123 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: U-87MG, HeLa, MCF7, Mouse spleen, Rat ovary, Rat lung; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane
Immunogen sequence: MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG
靶标信息
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: APG6; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197
基因别名: 4921513J16Rik; 5430417M23Rik; Atg6; Becn1
UniProt ID: (Rat) Q91XJ1, (Mouse) O88597
Entrez Gene ID: (Rat) 114558, (Mouse) 56208
autophagosome assembly
mitophagy
response to hypoxia
autophagy
cellular response to nitrogen starvation
lysosome organization
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of macroautophagy
CVT pathway
response to vitamin E
response to drug
nucleophagy
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
defense response to virus
response to other organism
negative regulation of cell death
cellular response to aluminum ion
cellular response to epidermal growth factor stimulus
positive regulation of mitophagy
cytokinesis
angiogenesis
cell cycle
mitotic metaphase plate congression
macroautophagy
regulation of cytokinesis
receptor catabolic process
cellular response to glucose starvation
negative regulation of apoptotic process
cell division
mitophagy in response to mitochondrial depolarization
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of reactive oxygen species metabolic process
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