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Invitrogen
ZNF350 Polyclonal Antibody
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ZNF350 Antibody (PA5-96826) in WB
Western blot analysis of ZNF350 in Jurkat cells. Samples were incubated with ZNF350 Polyclonal antibody (Product # PA5-96826) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96826
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 285-532 of human ZNF350 (NP_0676453)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.66 mg/mL
规格
66 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Jurkat, THP-1, Mouse thymus; Cellular Location: Nucleus, Nucleus matrix
Immunogen sequence: TGEKPYICSE CGKGFIQKGN LIVHQRIHTG EKPYICNECG KGFIQKTCLI AHQRFHTGKT PFVCSECGKS CSQKSGLIKH QRIHTGEKPF ECSECGKAFS TKQKLIVHQR THTGERPYGC NECGKAFAYM SCLVKHKRIH TREKQEAAKV ENPPAERHSS LHTSDVMQEK NSANGATTQV PSVAPQTSLN ISGLLANRNV VLVGQPVVRC AASGDNRGFA QDRNLVNAVN VVVPSVINYV LFYVTENP
靶标信息
ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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