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Invitrogen
Securin Polyclonal Antibody
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Securin Antibody (PA5-96997) in IHC (P)
Immunohistochemistry analysis of Securin in paraffin-embedded human lung cancer. Samples were incubated with Securin Polyclonal antibody (Product # PA5-96997) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96997
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human PTTG1 (NP_0012693111)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.87 mg/mL
规格
87 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI; Positive Samples: SW480, Jurkat, HeLa, Mouse stomach, Mouse thymus, Mouse spleen, Rat testis; Cellular Location: Cytoplasm, Nucleus
靶标信息
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; Securin
基因别名: AW555095; C87862; Pttg; Pttg1; Pttg3
UniProt ID: (Mouse) Q9CQJ7, (Rat) P97613
Entrez Gene ID: (Mouse) 30939, (Rat) 64193
regulation of cell growth
DNA repair
cellular response to DNA damage stimulus
cell cycle
chromosome segregation
mitotic nuclear division
negative regulation of cell proliferation
cellular process
negative regulation of endopeptidase activity
homologous chromosome segregation
chromosome organization
cell division
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
