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Invitrogen
CALCRL Polyclonal Antibody
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CALCRL Antibody (PA5-97108) in WB
Western blot analysis of CALCRL in extracts of various cell lines. Samples were incubated with CALCRL Polyclonal antibody (Product # PA5-97108) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-97108
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.52 mg/mL
规格
52 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: A-549, MCF7, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor
基因别名: AV071593; Calcrl; Cgrpr; CLR; CRLR; RATCRLR; RNCLR
UniProt ID: (Rat) Q63118, (Mouse) Q9R1W5
Entrez Gene ID: (Rat) 25029, (Mouse) 54598
angiogenesis
cAMP biosynthetic process
calcium ion transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
positive regulation of cell proliferation
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of smooth muscle contraction
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
cellular response to sucrose stimulus
signal transduction
cell surface receptor signaling pathway
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