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Invitrogen

Phospho-c-Raf (Ser338) Polyclonal Antibody

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Phospho-c-Raf (Ser338) Polyclonal Antibody

Product Details

PA5-97369

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Amount

22 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809171

Product Specific Information

Positive Samples: NIH/3T3; Cellular Location: Cell membrane, Cytoplasm, Mitochondrion, Nucleus

Immunogen sequence: RDSSY

Target Information

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-RAF; C-Raf proto-oncogene, serine/threonine kinase; cRaf; Craf1 transforming; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; Proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; sarcoma 3611 oncogene; unnamed protein product; v-raf-1 leukemia viral oncogene 1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; vraf1 murine le

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Gene Aliases: 6430402F14Rik; AA990557; BB129353; c-Raf; CMD1NN; CRAF; Craf1; D830050J10Rik; NS5; RAF; Raf-1; RAF1; v-Raf

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UniProt ID: (Mouse) Q99N57, (Rat) P11345

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Entrez Gene ID: (Human) 5894, (Mouse) 110157, (Rat) 24703

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Function(s)
protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding adenylate cyclase activator activity enzyme binding small GTPase binding identical protein binding protein serine kinase activity nucleotide binding receptor signaling protein activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups Ras GTPase binding mitogen-activated protein kinase kinase binding metal ion binding protein heterodimerization activity non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade protein phosphorylation apoptotic process signal transduction neuromuscular junction development negative regulation of cell proliferation insulin receptor signaling pathway Schwann cell development negative regulation of protein complex assembly positive regulation of peptidyl-serine phosphorylation regulation of Rho protein signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway wound healing myelination regulation of apoptotic process negative regulation of apoptotic process positive regulation of MAPK cascade regulation of cell differentiation insulin-like growth factor receptor signaling pathway interferon-gamma-mediated signaling pathway activation of MAPKK activity response to hypoxia cellular glucose homeostasis positive regulation of protein phosphorylation phosphorylation cell differentiation somatic stem cell population maintenance intracellular signal transduction insulin secretion involved in cellular response to glucose stimulus response to muscle stretch intermediate filament cytoskeleton organization positive regulation of transcription from RNA polymerase II promoter neurotrophin TRK receptor signaling pathway death-inducing signaling complex assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors heart development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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