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Invitrogen
HRG Polyclonal Antibody
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FIGURE: 1 / 2
HRG Antibody (PA5-97841) in IHC (P)
Immunohistochemical analysis of HRG in paraffin embedded human liver cancer using a HRG polyclonal antibody (Product # PA5-97841) at a dilution of 1:400. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected b... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-97841
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Histidine-rich glycoprotein protein (412-511AA)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; histidine-rich glycoprotein precursor; HPRG; unnamed protein product
Gene Aliases: HPRG; HRG; HRGP; THPH11
Entrez Gene ID: (Human) 3273
positive regulation of immune response to tumor cell
negative regulation of cell adhesion
negative regulation of cell proliferation
regulation of gene expression
regulation of platelet activation
negative regulation of lamellipodium assembly
negative regulation of angiogenesis
platelet activation
regulation of blood coagulation
negative regulation of cell growth
regulation of actin cytoskeleton organization
negative regulation of cell adhesion mediated by integrin
positive regulation of apoptotic process
negative regulation of blood vessel endothelial cell migration
defense response to fungus
positive regulation of focal adhesion assembly
negative regulation of fibrinolysis
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of blood vessel remodeling
negative regulation of endothelial cell chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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