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Invitrogen
PSMA7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-97949
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Proteasome subunit alpha type-7 protein (5-232AA)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-4; epididymis secretory protein Li 276; proteasome (prosome, macropain) subunit, alpha type, 7; proteasome subunit alpha 4; proteasome subunit alpha 7; Proteasome subunit alpha type-7; Proteasome subunit alpha-4; Proteasome subunit RC6-1; Proteasome subunit XAPC7; RP5-1005F21.4; testicular tissue protein Li 151; unnamed protein product
Gene Aliases: C6; C6-I; HEL-S-276; HSPC; PSMA7; RC6-1; XAPC7
UniProt ID: (Mouse) Q9Z2U0
Entrez Gene ID: (Human) 5688, (Mouse) 26444
immune system process
DNA repair
ubiquitin-dependent protein catabolic process
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
proteasomal protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
protein catabolic process
sperm motility
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
response to interferon-gamma
proteasome-mediated ubiquitin-dependent protein catabolic process
CD8-positive, alpha-beta T cell differentiation
thymic T cell selection
T-helper 1 cell differentiation
negative regulation of regulatory T cell differentiation
regulation of proteasomal protein catabolic process
cellular response to type I interferon
T-helper 17 cell differentiation
CD8-positive, alpha-beta T cell homeostasis
regulation of G1/S transition of mitotic cell cycle
proteolysis
proteolysis involved in cellular protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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