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Invitrogen
SHMT1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-98146
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Serine hydroxymethyltransferase, cytosolic protein (324-483AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.53 mg/mL
规格
53 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic serine hydroxymethyltransferase; F20D10.50; F20D10_50; Glycine hydroxymethyltransferase; L-allo-threonine/L-threonine aldolase SHMT1; MGC15229; MGC24556; SERINE HYDROXYMETHYLTRANSFERASE 1; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SERINE TRANSHYDROXYMETHYLASE; SERINE TRANSHYDROXYMETHYLTRANSFERASE; serine transhydroxymethyltransferase 1; SHM1; SHMT; STM; unnamed protein product
基因别名: CSHMT; hcSHMT; SHMT; SHMT1
Entrez Gene ID: (Human) 6470
translation repressor activity, nucleic acid binding
glycine hydroxymethyltransferase activity
threonine aldolase activity
protein binding
lamin binding
L-allo-threonine aldolase activity
aldehyde-lyase activity
pyridoxal phosphate binding
small molecule binding
identical protein binding
protein homodimerization activity
mRNA 5'-UTR binding
phenylserine aldolase activity
serine binding
hydroxytrimethyllysine aldolase activity
'de novo' pyrimidine nucleobase biosynthetic process
dTMP biosynthetic process
DNA replication
glycine metabolic process
glycine biosynthetic process
L-serine metabolic process
L-serine catabolic process
one-carbon metabolic process
purine nucleobase biosynthetic process
negative regulation of translation
tetrahydrofolate interconversion
carnitine biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
protein homotetramerization
cellular response to tetrahydrofolate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
