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Invitrogen
Amylin Polyclonal Antibody
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Amylin Antibody (PA5-98309) in WB
Western Blot analysis of Amylin using a Amylin Polyclonal antibody (Product # PA5-98309) at a concentration of 1 µg/mL. Positive WB detected in: Mouse heart tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 10 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-98309
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Islet amyloid polypeptide protein (34-70AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Amylin; amylin peptide; amylin precursor; DAP; Diabetes-associated peptide; IAPP; Insulinoma amyloid peptide; Islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); Rabbit Anti-Amylin; unnamed protein product
基因别名: DAP; IAP; IAPP
UniProt ID: (Mouse) P12968
Entrez Gene ID: (Human) 3375, (Mouse) 15874
apoptotic process
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of protein complex assembly
protein destabilization
eating behavior
positive regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of calcium-mediated signaling
protein homooligomerization
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
calcitonin family receptor signaling pathway
amylin receptor signaling pathway
positive regulation of cAMP/PKA signal transduction
amylin receptor 1 signaling pathway
amylin receptor 2 signaling pathway
amylin receptor 3 signaling pathway
negative regulation of amyloid fibril formation
amyloid fibril formation
sensory perception of pain
negative regulation of cell differentiation
negative regulation of bone resorption
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
