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Invitrogen
HSPA1B Polyclonal Antibody
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HSPA1B Antibody (PA5-98348) in ICC/IF
Immunofluorescent analysis of HSPA1B in PC-3 cells using a HSPA1B polyclonal antibody (Product # PA5-98348) at a dilution of 1:106. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-98348
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Heat shock 70 kDa protein 1B protein (418-641AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.98 mg/mL
规格
98 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; Heat shock protein; Heat shock protein family A member 1A; Heat shock protein family A member 1B; HSP; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1/HSP70.2; HSP70I; unnamed protein product
基因别名: HSP70-1; HSP70-1B; HSP70-2; HSP70.1; HSP70.2; HSP72; HSPA1; HSPA1A; HSPA1B; HSX70
Entrez Gene ID: (Human) 3304
G-protein coupled receptor binding
RNA binding
receptor binding
protein binding
ATP binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
histone deacetylase binding
protein binding involved in protein folding
C3HC4-type RING finger domain binding
ATP-dependent protein disaggregase activity
mRNA catabolic process
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of cell growth
regulation of protein ubiquitination
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of interleukin-8 production
cellular response to oxidative stress
cellular response to heat
protein refolding
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of erythrocyte differentiation
ATP metabolic process
protein stabilization
cellular heat acclimation
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to steroid hormone stimulus
positive regulation of microtubule nucleation
negative regulation of inclusion body assembly
regulation of mitotic spindle assembly
positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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