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Invitrogen
HIF3A Polyclonal Antibody
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HIF3A Antibody (PA5-99079) in IHC (P)
Immunohistochemical analysis of HIF3A in paraffin embedded human liver tissue using a HIF3A polyclonal antibody (Product # PA5-99079) at a dilution of 1:500. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detect... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99079
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Hypoxia-inducible factor 3-alpha protein (516-669AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: basic-helix-loop-helix-PAS protein MOP7; bHLH/PAS protein; class E basic helix-loop-helix protein 17; HIF-3-alpha; HIF3 alpha; HIF3-alpha; HIF3-alpha-1; HIPAS; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor three alpha; inhibitory PAS domain protein; member of PAS protein 7; neonatal and embryonic PAS protein; PAS domain-containing protein 7; unnamed protein product
基因别名: bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7; NEPAS; PASD7
UniProt ID: (Human) Q9Y2N7, (Mouse) Q0VBL6
Entrez Gene ID: (Human) 64344, (Mouse) 53417
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
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