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Invitrogen
MUTYH Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99217
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MUTYH(Accession Q9UIF7), corresponding to amino acid residues L156-Q206.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MUTYH.
靶标信息
MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; adenine-DNA glycosylase; hMYH; MGC4416; mMYH; MutY homolog; mutY homolog alpha; OTTHUMP00000009098; OTTHUMP00000009102; rMYH; RP4-534D1.2; the full-length form type A, 5' region
基因别名: 5730495A01Rik; MUTYH; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; MYH
UniProt ID: (Mouse) Q99P21, (Rat) Q8R5G2
Entrez Gene ID: (Mouse) 70603, (Rat) 170841
purine-specific mismatch base pair DNA N-glycosylase activity
catalytic activity
uracil DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
MutSalpha complex binding
DNA-3-methylbase glycosylase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
MutLalpha complex binding
MutLbeta complex binding
MutSbeta complex binding
DNA glycosylase
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