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Invitrogen

Phospho-HDAC3 (Ser424) Polyclonal Antibody

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Phospho-HDAC3 (Ser424) Polyclonal Antibody

Product Details

PA5-99339

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HDAC3(Accession O15379), corresponding to amino acid residues around phosphorylated Ser424.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818272

Product Specific Information

Antibody detects endogenous levels of HDAC3 only when phosphorylated at Serine 424.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45

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Gene Aliases: AW537363; HDAC3

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UniProt ID: (Mouse) O88895, (Rat) Q6P6W3

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Entrez Gene ID: (Mouse) 15183, (Rat) 84578

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Function(s)
DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding hydrolase activity enzyme binding cyclin binding histone deacetylase activity (H3-K14 specific) chromatin DNA binding NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) protein deacetylase activity histone deacetylase activity (H4-K16 specific) histone deacetylase binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) GTPase binding NF-kappaB binding NAD-dependent histone deacetylase activity (H3-K18 specific)
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated protein deacetylation regulation of mitotic cell cycle chromatin modification histone deacetylation regulation of protein stability positive regulation of TOR signaling negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production circadian regulation of gene expression regulation of multicellular organism growth positive regulation of transcription factor import into nucleus negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of protein export from nucleus spindle assembly cellular response to fluid shear stress positive regulation of type B pancreatic cell apoptotic process negative regulation of cardiac muscle cell differentiation negative regulation of myotube differentiation response to nutrient levels response to drug histone H3-K9 modification histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus response to dexamethasone
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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