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Invitrogen
TDG Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99413
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TDG(Accession Q13569), corresponding to amino acid residues P70-L120.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total TDG.
靶标信息
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-JUN leucine zipper interactive protein JZA-3; G/T mismatch-specific thymine DNA glycosylase; hTDG; Thymine-DNA glycosylase
基因别名: E130317C12Rik; JZA-3; Jza1; TDG
UniProt ID: (Mouse) P56581
Entrez Gene ID: (Rat) 114521, (Mouse) 21665
RNA polymerase II transcription cofactor activity
double-stranded DNA binding
protein kinase C binding
transcription factor binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
hydrolase activity, hydrolyzing N-glycosyl compounds
DNA N-glycosylase activity
protein domain specific binding
mismatched DNA binding
SUMO binding
protein homodimerization activity
structure-specific DNA binding
protein binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
base-excision repair
mismatch repair
transcription from RNA polymerase II promoter
negative regulation of protein binding
negative regulation of chromatin binding
regulation of gene expression, epigenetic
DNA demethylation
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
metabolic process
embryo development
chromatin modification
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
