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Invitrogen
PKD1/2/3/PKC mu Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99550
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRKD1(Accession Q15139), corresponding to amino acid residues L714-L764.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PKD1/2/3/PKC mu.
靶标信息
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKD2; protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase EPK2; unnamed protein product
基因别名: 4930557O20Rik; 5730497N19Rik; CHDED; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; RGD1308054
UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2
Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Mouse) 75292, (Rat) 313834
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
protein kinase C binding
protein binding
ATP binding
kinase activity
heat shock protein binding
identical protein binding
protein serine kinase activity
phosphatidylinositol 3-kinase activator activity
nucleotide binding
positive regulation of endothelial cell proliferation
protein phosphorylation
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of endothelial cell migration
sphingolipid biosynthetic process
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of blood vessel endothelial cell migration
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
endothelial tube morphogenesis
regulation of T cell apoptotic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of DNA biosynthetic process
positive regulation of endothelial cell chemotaxis
Golgi organization
signal transduction
integrin-mediated signaling pathway
positive regulation of autophagy
positive regulation of gene expression
regulation of keratinocyte proliferation
positive regulation of neuron projection development
regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
cellular response to amino acid starvation
cellular response to oxidative stress
positive regulation of protein import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of osteoblast differentiation
positive regulation of cell size
negative regulation of endocytosis
protein autophosphorylation
positive regulation of protein export from nucleus
Golgi vesicle transport
defense response to Gram-negative bacterium
positive regulation of protein kinase B signaling
positive regulation of sarcomere organization
transepithelial transport
cellular response to hydroperoxide
response to norepinephrine
cellular response to norepinephrine stimulus
positive regulation of peptide hormone secretion
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
cellular response to angiotensin
cellular response to phorbol 13-acetate 12-myristate
cellular response to endothelin
regulation of integrin-mediated signaling pathway
positive regulation of cell communication
positive regulation of signaling
positive regulation of peptidyl-serine phosphorylation
cell-cell adhesion mediated by cadherin
regulation of release of sequestered calcium ion into cytosol
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