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Gibco
Human CXCL13 (BLC/BCA-1) Recombinant Protein
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产品信息
PHC0052
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
Amount
20 µg
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Carrier-Free
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1 mg/mL. The solution can be diluted into other aqueous buffers or stored at 4°C for 1 week or =-20°C for future use.
Storage: The lyophilized BCA-1 is best-stored desiccated below 0°C. Reconstituted BCA-1 should be stored in working aliquots at =-20°C. Avoid freeze/thaw cycles.
靶标信息
CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt's Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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