Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells.
AuthorsYang L, Baltimore D,
JournalProc Natl Acad Sci U S A
PubMed ID15758071
A method to genetically program mouse hematopoietic stem cells to develop into functional CD8 or CD4 T cells of defined specificity in vivo is described. For this purpose, a bicistronic retroviral vector was engineered that efficiently delivers genes for both alpha and beta chains of T cell receptor (TCR) to ... More