Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.
AuthorsColton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP,
JournalJ Neuroinflammation
PubMed ID17005052
Microglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amyloid beta-peptide fragments (Abeta) of the amyloid precursor protein (APP). Numerous studies have shown that the immune cells ... More