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Invitrogen
Human CDK9/Cyclin T1, His Tag Recombinant Protein
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产品信息
PR7541B
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
Full length
标签
His-tag
分子量
46.9-84.8 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris, pH 7.5, with 0.02% Triton X-100, 50% glycerol, 150mM NaCl, 0.5mM EDTA, 2mM DTT
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Full Length
靶标信息
Cyclin-dependent kinase 9 (CDK9) and Cyclin T1 form the positive transcription elongation factor b (p-TEFb) complex, which is crucial for transcriptional regulation and mRNA maturation. CDK9 is a transcriptional kinase expressed widely across human tissues, with notably higher levels in terminally differentiated cells, influencing transcriptional elongation by phosphorylating the RNA polymerase II C-terminal domain. This kinase's gene is mapped to chromosome 9q34.1 and produces two isoforms through two distinct promoters. CDK9, when coupled with Cyclin T1, modulates oncogene expression and activity, representing essential roles in cell survival and proliferation. The dysregulation of CDK9/Cyclin T1's activity has connections to tumorigenesis, highlighting their importance in cancer biology as potential therapeutic targets. Their complex operation also involves acetylation changes crucial for functional modulation. The interaction of CDK9 with other regulatory proteins emphasizes its versatile roles in cellular physiology beyond what is seen in classical cell cycle control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-2K; CDC2-related kinase; CDK9-associated C-type protein; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; cyclin C-related protein; Cyclin-dependent kinase 9; Cyclin-T1; CycT1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit
基因别名: C-2k; CCNT; CCNT1; CDC2L4; CDK9; CTK1; CYCT1; HIVE1; PITALRE; TAK
UniProt ID: (Human) O60563, (Human) P50750
Entrez Gene ID: (Human) 904, (Human) 1025
