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Invitrogen
Human CDK6/Cyclin D1, GST Tag Recombinant Protein
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Product Details
PR8422B
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
Full length
Tag
GST-tag
Molecular weight
66.4-61.2 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 0.02% Triton X-100, 50% glycerol, 150mM NaCl, 0.5mM EDTA, 2mM DTT
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
Cyclin-dependent kinase 6 (CDK6) and Cyclin D1 are critical components of the cell cycle regulation, particularly in the transition from the G1 to the S phase. CDK6 is a protein kinase that requires association with cyclins, such as Cyclin D1, to become enzymatically active. This partnership is essential for phosphorylating target substrates that drive cell cycle progression. CDK6 and Cyclin D1 together form complexes that regulate the retinoblastoma protein (Rb) pathway, which is a key mechanism controlling cell proliferation. The expression and activation of CDK6/Cyclin D1 complexes are tightly regulated, and imbalances can contribute to oncogenesis. Structural studies have shown that CDK6 has a unique C-terminal region crucial for its nuclear transport and localization, which is essential for its function. Cyclin D1's dynamics-its expression, accumulation, and degradation-are pivotal in its regulatory roles, especially its interactions with CDK4 and CDK6. In cancer, genetic alterations affecting CDK6 and Cyclin D1 can lead to uncontrolled cell division, emphasizing their significance in cancer progression and as potential therapeutic targets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; Cell division protein kinase 6; Cyclin-dependent kinase 6; G1/S-specific cyclin-D1; PRAD1 oncogene; Serine/threonine-protein kinase PLSTIRE
Gene Aliases: BCL1; CCND1; CDK6; CDKN6; D11S287E; MCPH12; PLSTIRE; PRAD1; U21B31
UniProt ID: (Human) P24385, (Human) Q00534
Entrez Gene ID: (Human) 595, (Human) 1021
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