Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury.
AuthorsRana SN, Li X, Chaudry IH, Bland KI, Choudhry MA
JournalJ Leukoc Biol
PubMed ID15728717
Previous studies have shown that alcohol (EtOH) ingestion before burn injury impaired intestinal barrier and immune function. This study determined whether EtOH and burn injury up-regulate interleukin (IL)-18 and whether IL-18 up-regulation following EtOH and burn injury is a cause for neutrophil recruitment and increased intestinal edema. Rats (250 g) ... More