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Invitrogen
Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag Recombinant Protein
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产品信息
PV6455
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
Full length
标签
His-tag
分子量
123.7-84.7 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM sodium phosphate, pH 7, with 25% glycerol, 0.1mM PMSF, 300mM NaCl, 0.25mM DTT, 150mM Imidazole
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is:
• Available in 3 convenient sizes
• Validated in our Adapta™ and Kinase Binding assays
• A full-length protein that can help advance your research when used in validated assays
Related assay platforms:
LanthaScreen™ Kinase Binding Assay
Adapta™ Kinase Activity Assay
Protein Form: Full Length, Recombinant, Active
The gene accession number for PIK3CB (p110β) is NP_006210 and for PIK3R1 (p85α) is NP_852664.1.
靶标信息
PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, catalytic, beta polypeptide; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p110 subunit beta; PI3-kinase regulatory subunit alpha; PI3-kinase subunit beta; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K-beta; PIK3CB; PIK3R1; PtdIns-3-kinase p110; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB
基因别名: AGM7; GRB1; IMD36; P110BETA; p85; p85-ALPHA; PI3K; PI3KBETA; PIK3C1; PIK3CB; PIK3R1
UniProt ID: (Human) P42338, (Human) P27986
Entrez Gene ID: (Human) 5291, (Human) 5295
