Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses.
AuthorsPeretti S, Shaw A, Blanchard J, Bohm R, Morrow G, Lifson JD, Gettie A, Pope M,
JournalBlood
PubMed ID15845898
'Herpes simplex viruses (HSV) infect human and murine dendritic cells (DCs) and interfere with their immunostimulatory functions in culture. HSV-2 infection increases human immunodeficiency virus (HIV) spread in patients, and DCs also promote HIV infection. We have studied these topics in rhesus macaque monocyte-derived DCs (moDCs) to set the stage ... More
TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.
AuthorsCarlisle RE, Heffernan A, Brimble E, Liu L, Jerome D, Collins CA, Mohammed-Ali Z, Margetts PJ, Austin RC, Dickhout JG,
JournalAm J Physiol Renal Physiol
PubMed ID22592641
'Epithelial-to-mesenchymal transition (EMT) contributes to renal fibrosis in chronic kidney disease. Endoplasmic reticulum (ER) stress, a feature of many forms of kidney disease, results from the accumulation of misfolded proteins in the ER and leads to the unfolded protein response (UPR). We hypothesized that ER stress mediates EMT in human ... More
Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer.
AuthorsHsu T, Mitragotri S,
JournalProc Natl Acad Sci U S A
PubMed ID21903933
'Delivery of macromolecules into cells and tissues such as skin is a major challenge. This obstacle poses a particular challenge for the delivery of siRNA where cellular and tissue level transport barriers need to be overcome. siRNAs are potential therapeutics for various dermatological diseases including psoriasis, atopic dermatitis, and cancer; ... More