Ligand-conjugated quantum dots monitor antigen uptake and processing by dendritic cells.
AuthorsCambi A, Lidke DS, Arndt-Jovin DJ, Figdor CG, Jovin TM
JournalNano Lett
PubMed ID17388641
The dendritic cell (DC) specific pathogen-uptake receptor (DC-SIGN) internalizes antigens for degradation and presentation onto MHC molecules. At the cell membrane, DC-SIGN forms nanoclusters that facilitate virus capture. However, internalized viruses, such as HIV-1, escape degradation. Here, we exploit ligand-conjugated, virus-sized, highly photostable quantum dots (QDs) to monitor in living ... More