Characterization of SynCAM surface trafficking using a SynCAM derived ligand with high homophilic binding affinity.
AuthorsBreillat C, Thoumine O, Choquet D,
JournalBiochem Biophys Res Commun
PubMed ID17548061
In order to better probe SynCAM function in neurons, we produced a fusion protein between the extracellular domain of SynCAM1 and the constant fragment of human IgG (SynCAM-Fc). Whether in soluble form or immobilized on latex microspheres, the chimera bound specifically to the surface of hippocampal neurons and recruited endogenous ... More