Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles.
AuthorsAllen PG
JournalNat Cell Biol
PubMed ID14557819
Regulated actin filament assembly is critical for eukaryotic cell physiology. Actin filaments are polar structures, and those with free high affinity or barbed ends are crucial for actin dynamics and cell motility. Actin filament barbed-end-capping proteins inhibit filament elongation after binding, and their regulated disassociation is proposed to provide a ... More