Visible-to-near IR quantum dot-based hypermulticolor high-content screening of herbal medicines for the efficacy monitoring of hair growth promotion and hair loss inhibition.
AuthorsKim MJ, Lim C, Lee JY, Im KR, Yoon KS, Song JM,
JournalJ Biomol Screen
PubMed ID23190736
'There is a growing interest in alopecia prevention strategies, as the number of alopecia patients is increasing. We examine the efficacy of herbal medicine for hair growth promotion/hair loss inhibition in two cell lines via Western blot and high-content screening (HCS). Nine herbal extracts were obtained from three different herbal ... More
DNA target sequence identification mechanism for dimer-active protein complexes.
AuthorsLandry MP, Zou X, Wang L, Huang WM, Schulten K, Chemla YR,
JournalNucleic Acids Res
PubMed ID23275566
Sequence-specific DNA-binding proteins must quickly and reliably localize specific target sites on DNA. This search process has been well characterized for monomeric proteins, but it remains poorly understood for systems that require assembly into dimers or oligomers at the target site. We present a single-molecule study of the target-search mechanism ... More