Total circulating cell-free miRNA in plasma as a predictive biomarker of the thyroid diseases.
AuthorsCaglar O, Cayir A
JournalJ Cell Biochem
PubMed ID30506793
Thyroid cancer is a common endocrine cancer. Great progress has been made in resolving its molecular mechanisms in recent years. The molecular changes observed in thyroid cancer can be used as biomarkers for diagnostic, prognostic and therapeutic purposes. MicroRNAs (miRNAs) are important components in biological and metabolic pathways, such as ... More
Tendon response to matrix unloading is determined by the patho-physiological niche.
AuthorsWunderli SL, Blache U, Beretta Piccoli A, Niederöst B, Holenstein CN, Passini FS, Silván U, Bundgaard L, Auf dem Keller U, Snedeker JG
JournalMatrix Biol
PubMed ID31917255
Although the molecular mechanisms behind tendon disease remain obscure, aberrant stromal matrix turnover and tissue hypervascularity are known hallmarks of advanced tendinopathy. We harness a tendon explant model to unwind complex cross-talk between the stromal and vascular tissue compartments. We identify the hypervascular tendon niche as a state-switch that gates ... More